Pseudomonic acid derivatives from a marine bacterium

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Abstract

The sponge Darwinella rosacea was found to harbor a host of marine microorganisms. One of these bacteria was identified as a marine Alteromonas species. The organic extract of this bacterium was antimicrobial, and the activity was traced to two novel pseudomonic acid derivatives 1 and 7. The structures of these compounds were elucidated by interpretation of the spectral data and extensive use of 2-dimensional NMR techniques and NOE studies on the parent compounds and the acetate derivatives 2 and 8.

Original languageEnglish
Pages (from-to)1165-1169
Number of pages5
JournalExperientia
Volume48
Issue number11-12
DOIs
StatePublished - Dec 1992

Keywords

  • Alteromonas
  • antimicrobial activity
  • Darwinella rosacea
  • marine bacterium
  • Pseudomonic acid derivatives

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