Regulatory mechanisms of metabolic flexibility in the dark-eyed junco (Junco hyemalis)

Maria Stager, David L. Swanson, Zachary A. Cheviron

Research output: Contribution to journalArticlepeer-review

Abstract

Small temperate birds reversibly modify their aerobic performance to maintain thermoregulatory homeostasis under seasonally changing environmental conditions and these physiological adjustments may be attributable to changes in the expression of genes in the underlying regulatory networks. Here, we report the results of an experimental procedure designed to gain insight into the fundamental mechanisms of metabolic flexibility in the dark-eyed junco (Junco hyemalis). We combined genomic transcriptional profiles with measures of metabolic enzyme activities and wholeanimal thermogenic performance from juncos exposed to four 6-week acclimation treatments that varied in temperature (cold, 3°C; warm, 24°C) and photoperiod (short day, 8 h light:16 h dark; long day, 16 h light:8 h dark). Cold-acclimated birds increased thermogenic capacity compared with warm-acclimated birds, and this enhanced performance was associated with upregulation of genes involved in muscle hypertrophy, angiogenesis, and lipid transport and oxidation, as well as with catabolic enzyme activities. These physiological changes occurred over ecologically relevant timescales, suggesting that birds make regulatory adjustments to interacting, hierarchical pathways in order to seasonally enhance thermogenic capacity.

Original languageEnglish
Pages (from-to)767-777
Number of pages11
JournalJournal of Experimental Biology
Volume218
Issue number5
DOIs
StatePublished - Mar 1 2015

Keywords

  • Phenotypic flexibility
  • Seasonal adjustments
  • Transcriptomics
  • Winter acclimatization

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