Abstract
Human serum albumin (HSA) was encapsulated in a 50:50 copolymer of DL-lactide/glycolide in the form of microspheres. These microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20- to 30-day period. We show that HSA can be successfully incorporated into microspheres and released intact from these microspheres into various buffer systems at 37°C. A continuous release of the protein could be achieved in physiological buffers at 37°C over a 20- to 30-day period from microspheres with high protein loadings (11.6%). These results demonstrate the potential of poly(DL-lactide-co-glycolide) microspheres for continuous delivery of large proteins.
Original language | English |
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Pages (from-to) | 1190-1194 |
Number of pages | 5 |
Journal | Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists |
Volume | 7 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1990 |
Keywords
- biodegradable microspheres
- human serum albumin
- poly(lactide-co-glycolide)
- protein release
- protein stability