Release of Human Serum Albumin from Poly(lactide-co-glycolide) Microspheres

Maninder S. Hora, Rajsharan K. Rana, Jack H. Nunberg, Thomas R. Tice, Richard M. Gilley, Michael E. Hudson

Research output: Contribution to journalArticlepeer-review

Abstract

Human serum albumin (HSA) was encapsulated in a 50:50 copolymer of DL-lactide/glycolide in the form of microspheres. These microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20- to 30-day period. We show that HSA can be successfully incorporated into microspheres and released intact from these microspheres into various buffer systems at 37°C. A continuous release of the protein could be achieved in physiological buffers at 37°C over a 20- to 30-day period from microspheres with high protein loadings (11.6%). These results demonstrate the potential of poly(DL-lactide-co-glycolide) microspheres for continuous delivery of large proteins.

Original languageEnglish
Pages (from-to)1190-1194
Number of pages5
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume7
Issue number11
DOIs
StatePublished - Nov 1990

Keywords

  • biodegradable microspheres
  • human serum albumin
  • poly(lactide-co-glycolide)
  • protein release
  • protein stability

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