Respiratory damage in children exposed to urban pollution

Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Lynn A. Fordham, Gildardo Valencia-Salazar, Charles J. Chung, Antonio Rodriguez-Alcaraz, Rogelio Paredes, Daina Variakojis, Anna Villarreal-Calderón, Lourdes Flores-Camacho, Angelina Antunez-Solis, Carlos Henríquez-Roldán, Milan J. Hazucha

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Southwest Metropolitan Mexico City (SWMMC) children are chronically exposed to complex mixtures of air pollutants. In a cross-sectional arm of our study, we investigated the association between exposure to SWMMC atmosphere and nasal abnormalities, hyperinflation, and interstitial markings assessed by chest X-rays, lung function changes, several serum cytokines, and endothelin-1 in 174 children aged 5-17 years vs. 27 control children residents in low-polluted areas. Control children had no nasal lesions, and only one child showed an abnormal chest X-ray. SWMMC children exhibited nasal abnormalities (22%), hyperinflation (67%), interstitial markings (49%), and a mild restrictive pattern by spirometry (10%). Interstitial markings were associated with a decrease in predicted values of FEF25-75, FEF75, and the FEV1/FVC ratio. Boys had a higher probability of developing interstitial markings with age (P=0.004). Blood smear findings included toxic granulations in neutrophils and schistocytes. SWMMC children had more serum IL10 and IL6 and less IL8 than controls. In a longitudinal arm of our study, we found a significant seasonal drop in FVC and FEV1 associated with a 6-month period of high ozone and PM10 levels. Our data strongly suggest that a lifelong exposure to urban air pollution causes respiratory damage in children. Moreover, a cytokine network becomes imbalanced, with a shift towards upregulation of anti-inflammatory cytokines. Consequently, these children are potentially at risk for developing chronic lung disease and other systemic effects later in life.

Original languageEnglish
Pages (from-to)148-161
Number of pages14
JournalPediatric Pulmonology
Volume36
Issue number2
DOIs
StatePublished - Aug 1 2003

Keywords

  • Cytokines
  • ET-1
  • Ozone
  • Particulate matter
  • Spirometry
  • X-rays

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