RNA granules in germ cells

Ekaterina Voronina, Geraldine Seydoux, Paolo Sassone-Corsi, Ippei Nagamori

Research output: Contribution to journalReview articlepeer-review

267 Scopus citations

Abstract

"Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development. In this review, we focus on recent advances in our understanding of germ granule assembly, dynamics, and function. One hypothesis is that germ granules operate as hubs for the posttranscriptional control of gene expression, a function at the core of the germ cell differentiation program.

Original languageEnglish
JournalCold Spring Harbor Perspectives in Biology
Volume3
Issue number12
DOIs
StatePublished - Dec 2011

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