Role of the aryl hydrocarbon receptor (AhR) in lung inflammation

Research output: Contribution to journalReview articlepeer-review

Abstract

Millions of individuals worldwide are afflicted with acute and chronic respiratory diseases, causing temporary and permanent disabilities and even death. Oftentimes, these diseases occur as a result of altered immune responses. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acts as a regulator of mucosal barrier function and may influence immune responsiveness in the lungs through changes in gene expression, cell-cell adhesion, mucin production, and cytokine expression. This review updates the basic immunobiology of the AhR signaling pathway with regards to inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease, and silicosis following data in rodent models and humans. Finally, we address the therapeutic potential of targeting the AhR in regulating inflammation during acute and chronic respiratory diseases.

Original languageEnglish
Pages (from-to)693-704
Number of pages12
JournalSeminars in Immunopathology
Volume35
Issue number6
DOIs
StatePublished - Nov 2013

Keywords

  • Aryl hydrocarbon receptor
  • Asthma
  • Chronic obstructive pulmonary disease
  • Inflammation
  • Lung
  • Silicosis

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