Sequoiatones A and B: Novel antitumor metabolites isolated from a redwood endophyte

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Sequoiatones A and B were isolated from the fungus Aspergillus parasiticus, an endophytic fungus of the coast redwood, Sequoia sempervirens. The compounds were isolated from the methanol extract of the mycelial mat of the fungus when grown in liquid culture for 21 days. The compounds were isolated because of their brine shrimp lethality, which served as an excellent guide for chromatographic purification. Full details of the isolation and characterization of sequoiatones A and B are provided herein, along with the test results from the NCI human tumor 60 cell-line screen.

Original languageEnglish
Pages (from-to)5479-5484
Number of pages6
JournalJournal of Organic Chemistry
Volume64
Issue number15
DOIs
StatePublished - Jul 23 1999

Fingerprint

Dive into the research topics of 'Sequoiatones A and B: Novel antitumor metabolites isolated from a redwood endophyte'. Together they form a unique fingerprint.

Cite this