Sex and the lung: Observations, hypotheses, and future directions

Deborah R. Liptzin, Louis I. Landau, Lynn M. Taussig

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


Summary Sex-related differences in a variety of lung diseases in infants and young children are reviewed, including respiratory distress syndrome, and chronic lung disease of prematurity, lower respiratory tract illnesses and wheezing, asthma, diffuse, and interstitial lung diseases, and cystic fibrosis. Differences in anatomy and physiology, such as airway size, airway muscle bulk, airway reactivity, airway tone, and cough reflexes may explain much of these sex differences. Better understanding of sex-related lung differences could help personalize respiratory treatment. Pediatr Pulmonol. 2015; 50:1159-1169.

Original languageEnglish
Pages (from-to)1159-1169
Number of pages11
JournalPediatric Pulmonology
Issue number12
StatePublished - Dec 1 2015


  • females
  • gender
  • male-female ratio of lung diseases
  • males
  • respiratory illness
  • sex


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