Single application thixotropic antibiotic delivery systems for otitis externa

Monica A. Serban, Bogdan A. Serban, J. B. Alverson, N. D. Priestley

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Outer ear infections (otitis externa or OE) affect an estimated 10% of people in their lifetime, with associated healthcare costs amounting to over $500 million. The disease has a bacterial etiology, is mostly treatable in the general population with topical antibiotics regimes, and can be supplemented in severe cases with systemic counterparts. However, incorrect application or non-compliance with administration schedule of antibiotics leads to infection persistence, recurrence and potentially, development of antibiotic resistant bacterial strains. In diabetic or elderly patients, the infection can be life threatening as it can progress into necrotizing or malignant otitis externa (MOE), with severe health consequences. In recent years, the incidence rate of MOE has seen a significant increase and has been associated with antibiotic resistant bacterial strains. There is therefore a critical need to develop safe and effective therapies for the treatment of OE and prevention of MOE. Our research is focused on the development of an ototopical antibiotic delivery system that is liquid when sheared and could be deployed easily though a syringe or drop dispenser, but that gels rapidly in place once the shear stress is removed (thixotropic). Such a delivery system would have the benefits of simple and effective topical application, would eliminate the risk of antibiotic administration regime noncompliance, and would deliver in situ active components at effective concentrations.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages51
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period04/3/1904/6/19

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