TY - GEN
T1 - Single application thixotropic antibiotic delivery systems for otitis externa
AU - Serban, Monica A.
AU - Serban, Bogdan A.
AU - Alverson, J. B.
AU - Priestley, N. D.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Outer ear infections (otitis externa or OE) affect an estimated 10% of people in their lifetime, with associated healthcare costs amounting to over $500 million. The disease has a bacterial etiology, is mostly treatable in the general population with topical antibiotics regimes, and can be supplemented in severe cases with systemic counterparts. However, incorrect application or non-compliance with administration schedule of antibiotics leads to infection persistence, recurrence and potentially, development of antibiotic resistant bacterial strains. In diabetic or elderly patients, the infection can be life threatening as it can progress into necrotizing or malignant otitis externa (MOE), with severe health consequences. In recent years, the incidence rate of MOE has seen a significant increase and has been associated with antibiotic resistant bacterial strains. There is therefore a critical need to develop safe and effective therapies for the treatment of OE and prevention of MOE. Our research is focused on the development of an ototopical antibiotic delivery system that is liquid when sheared and could be deployed easily though a syringe or drop dispenser, but that gels rapidly in place once the shear stress is removed (thixotropic). Such a delivery system would have the benefits of simple and effective topical application, would eliminate the risk of antibiotic administration regime noncompliance, and would deliver in situ active components at effective concentrations.
AB - Outer ear infections (otitis externa or OE) affect an estimated 10% of people in their lifetime, with associated healthcare costs amounting to over $500 million. The disease has a bacterial etiology, is mostly treatable in the general population with topical antibiotics regimes, and can be supplemented in severe cases with systemic counterparts. However, incorrect application or non-compliance with administration schedule of antibiotics leads to infection persistence, recurrence and potentially, development of antibiotic resistant bacterial strains. In diabetic or elderly patients, the infection can be life threatening as it can progress into necrotizing or malignant otitis externa (MOE), with severe health consequences. In recent years, the incidence rate of MOE has seen a significant increase and has been associated with antibiotic resistant bacterial strains. There is therefore a critical need to develop safe and effective therapies for the treatment of OE and prevention of MOE. Our research is focused on the development of an ototopical antibiotic delivery system that is liquid when sheared and could be deployed easily though a syringe or drop dispenser, but that gels rapidly in place once the shear stress is removed (thixotropic). Such a delivery system would have the benefits of simple and effective topical application, would eliminate the risk of antibiotic administration regime noncompliance, and would deliver in situ active components at effective concentrations.
UR - http://www.scopus.com/inward/record.url?scp=85065420551&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065420551
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 51
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -