TY - JOUR
T1 - SNPs in ecology, evolution and conservation
AU - Morin, Phillip A.
AU - Luikart, Gordon
AU - Wayne, Robert K.
N1 - Funding Information:
We thank the Internet Science Education Project for funding the SNP workshop, Svante Pääbo and Mark Stoneking for useful presentations, and John Pollinger for designing Figure 1 . We are grateful to Pascal Gagneux and three anonymous reviewers for helpful comments. Members of the SNP workshop group contributed extensively and nearly equally to the ideas presented here.
PY - 2004/4
Y1 - 2004/4
N2 - Over the past two decades, new molecular genetic techniques have had substantial impacts on the fields of ecology, evolution and conservation. However, our current toolbox of genetic methodologies remains inadequate for answering many questions and there are significant technological and analytical limitations. We review the possible uses of single nucleotide polymorphisms (SNPs) as novel genetic markers for common questions in population genetics. Furthermore, we evaluate the potential of SNPs relative to frequently used genetic markers, such as microsatellite loci and mitochondrial DNA (mtDNA) sequences, and we discuss statistical power, analytical approaches, and technological improvements and limitations. Although ascertainment bias is a problem for some applications, SNPs can often generate equivalent statistical power whilst providing broader genome coverage and higher quality data than can either microsatellites or mtDNA, suggesting that SNPs could become an efficient and cost-effective genetic tool.
AB - Over the past two decades, new molecular genetic techniques have had substantial impacts on the fields of ecology, evolution and conservation. However, our current toolbox of genetic methodologies remains inadequate for answering many questions and there are significant technological and analytical limitations. We review the possible uses of single nucleotide polymorphisms (SNPs) as novel genetic markers for common questions in population genetics. Furthermore, we evaluate the potential of SNPs relative to frequently used genetic markers, such as microsatellite loci and mitochondrial DNA (mtDNA) sequences, and we discuss statistical power, analytical approaches, and technological improvements and limitations. Although ascertainment bias is a problem for some applications, SNPs can often generate equivalent statistical power whilst providing broader genome coverage and higher quality data than can either microsatellites or mtDNA, suggesting that SNPs could become an efficient and cost-effective genetic tool.
UR - http://www.scopus.com/inward/record.url?scp=1642271573&partnerID=8YFLogxK
U2 - 10.1016/j.tree.2004.01.009
DO - 10.1016/j.tree.2004.01.009
M3 - Review article
AN - SCOPUS:1642271573
SN - 0169-5347
VL - 19
SP - 208
EP - 216
JO - Trends in Ecology and Evolution
JF - Trends in Ecology and Evolution
IS - 4
ER -