Spermatogenesis and the Evolution of Mammalian Sex Chromosomes

Erica L. Larson; Emily E.K. Kopania; Jeffrey M. Good

doi:10.1016/j.tig.2018.06.003

Spermatogenesis and the Evolution of Mammalian Sex Chromosomes

Erica L. Larson
, Emily E.K. Kopania
, Jeffrey M. Good

Division of Biological and Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Developmental constraint and sexual conflict shape the evolution of heteromorphic sex chromosomes. These contrasting forces are perhaps strongest during spermatogenesis in species with XY males. In this review, we consider how the unique regulatory environment and selective pressures of spermatogenesis interact to impact sex chromosome evolution in mammals. We explore how each developmental phase of spermatogenesis influences sex chromosome gene content, structure, and rate of molecular evolution, and how these attributes may contribute to speciation. We argue that a developmental context is fundamental to understanding sex chromosome evolution and that an evolutionary perspective can shed new light on our understanding of sperm development.

Original language	English
Pages (from-to)	722-732
Number of pages	11
Journal	Trends in Genetics
Volume	34
Issue number	9
DOIs	https://doi.org/10.1016/j.tig.2018.06.003
State	Published - Sep 2018

Funding

We would like to thank Julie Cocquet, Art Woods, Doug Emlen, Scott Taylor, and three anonymous reviewers for their helpful feedback on this manuscript. E.E.K.K. was supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. ( DGE-1313190 ). Research by J.M.G. and E.L.L. on sex chromosome evolution and reproduction was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( R01-HD073439 and R01-HD094787 ) and the National Institute of General Medical Sciences ( R01-GM098536 ). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation or the National Institutes of Health. We would like to thank Julie Cocquet, Art Woods, Doug Emlen, Scott Taylor, and three anonymous reviewers for their helpful feedback on this manuscript. E.E.K.K. was supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. (DGE-1313190). Research by J.M.G. and E.L.L. on sex chromosome evolution and reproduction was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD073439 and R01-HD094787) and the National Institute of General Medical Sciences (R01-GM098536). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation or the National Institutes of Health.

Funder number
DGE-1313190
R01-GM098536
R01HD073439
R01-HD094787

Keywords

Genomic conflict
faster-X
hybrid male sterility
recombination
sex-biased expression
speciation

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10.1016/j.tig.2018.06.003

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title = "Spermatogenesis and the Evolution of Mammalian Sex Chromosomes",

abstract = "Developmental constraint and sexual conflict shape the evolution of heteromorphic sex chromosomes. These contrasting forces are perhaps strongest during spermatogenesis in species with XY males. In this review, we consider how the unique regulatory environment and selective pressures of spermatogenesis interact to impact sex chromosome evolution in mammals. We explore how each developmental phase of spermatogenesis influences sex chromosome gene content, structure, and rate of molecular evolution, and how these attributes may contribute to speciation. We argue that a developmental context is fundamental to understanding sex chromosome evolution and that an evolutionary perspective can shed new light on our understanding of sperm development.",

keywords = "Genomic conflict, faster-X, hybrid male sterility, recombination, sex-biased expression, speciation",

author = "Larson, \{Erica L.\} and Kopania, \{Emily E.K.\} and Good, \{Jeffrey M.\}",

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T1 - Spermatogenesis and the Evolution of Mammalian Sex Chromosomes

AU - Larson, Erica L.

AU - Kopania, Emily E.K.

AU - Good, Jeffrey M.

PY - 2018/9

Y1 - 2018/9

N2 - Developmental constraint and sexual conflict shape the evolution of heteromorphic sex chromosomes. These contrasting forces are perhaps strongest during spermatogenesis in species with XY males. In this review, we consider how the unique regulatory environment and selective pressures of spermatogenesis interact to impact sex chromosome evolution in mammals. We explore how each developmental phase of spermatogenesis influences sex chromosome gene content, structure, and rate of molecular evolution, and how these attributes may contribute to speciation. We argue that a developmental context is fundamental to understanding sex chromosome evolution and that an evolutionary perspective can shed new light on our understanding of sperm development.

AB - Developmental constraint and sexual conflict shape the evolution of heteromorphic sex chromosomes. These contrasting forces are perhaps strongest during spermatogenesis in species with XY males. In this review, we consider how the unique regulatory environment and selective pressures of spermatogenesis interact to impact sex chromosome evolution in mammals. We explore how each developmental phase of spermatogenesis influences sex chromosome gene content, structure, and rate of molecular evolution, and how these attributes may contribute to speciation. We argue that a developmental context is fundamental to understanding sex chromosome evolution and that an evolutionary perspective can shed new light on our understanding of sperm development.

KW - Genomic conflict

KW - faster-X

KW - hybrid male sterility

KW - recombination

KW - sex-biased expression

KW - speciation

UR - https://www.scopus.com/pages/publications/85050793054

U2 - 10.1016/j.tig.2018.06.003

DO - 10.1016/j.tig.2018.06.003

M3 - Review article

C2 - 30077434

AN - SCOPUS:85050793054

SN - 0168-9525

VL - 34

SP - 722

EP - 732

JO - Trends in Genetics

JF - Trends in Genetics

IS - 9

ER -

Spermatogenesis and the Evolution of Mammalian Sex Chromosomes

Abstract

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Keywords

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