Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-2́-deoxyguanosine oxidation by chromium(V)

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Abstract

(Chemical Equation Presented) Oxidation of the DNA lesion 8-oxo-2′-deoxyguanosine by the two electron oxidants N,N′- ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.

Original languageEnglish
Pages (from-to)4411-4414
Number of pages4
JournalOrganic Letters
Volume9
Issue number22
DOIs
StatePublished - Oct 25 2007

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