Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-2́-deoxyguanosine oxidation by chromium(V)

Peter G. Slade; Nigel D. Priestley; Kent D. Sugden

doi:10.1021/ol701667t

Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-2́-deoxyguanosine oxidation by chromium(V)

Peter G. Slade, Nigel D. Priestley, Kent D. Sugden

University of Montana

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

(Chemical Equation Presented) Oxidation of the DNA lesion 8-oxo-2′-deoxyguanosine by the two electron oxidants N,N′- ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.

Original language	English
Pages (from-to)	4411-4414
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	22
DOIs	https://doi.org/10.1021/ol701667t
State	Published - Oct 25 2007

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title = "Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-{\'2}-deoxyguanosine oxidation by chromium(V)",

abstract = "(Chemical Equation Presented) Oxidation of the DNA lesion 8-oxo-2′-deoxyguanosine by the two electron oxidants N,N′- ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.",

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year = "2007",

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AU - Slade, Peter G.

AU - Priestley, Nigel D.

AU - Sugden, Kent D.

PY - 2007/10/25

Y1 - 2007/10/25

N2 - (Chemical Equation Presented) Oxidation of the DNA lesion 8-oxo-2′-deoxyguanosine by the two electron oxidants N,N′- ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.

AB - (Chemical Equation Presented) Oxidation of the DNA lesion 8-oxo-2′-deoxyguanosine by the two electron oxidants N,N′- ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.

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JF - Organic Letters

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ER -

Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-2́-deoxyguanosine oxidation by chromium(V)

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