@article{a7dd55bcf5e0490893cdafa506989e85,
title = "Structural changes in glycogen phosphorylase induced by phosphorylation",
abstract = "A comparison of the refined crystal structures of dimeric glycogen phosphorylase b and a reveals structural changes that represent the first step in the activation of the enzyme. On phosphorylation of serine-14, the N-terminus of each subunit assumes an ordered helical conformation and binds to the surface of the dimer. The consequent structural changes at the N- and C-terminal regions lead to strengthened interactions between subunits and alter the binding sites for allosteric effectors and substrates.",
author = "Sprang, \{S. R.\} and Acharya, \{K. R.\} and Goldsmith, \{E. J.\} and Stuart, \{D. I.\} and K. Varvill and Fletterick, \{R. J.\} and Madsen, \{N. B.\} and Johnson, \{L. N.\}",
year = "1988",
doi = "10.1038/336215a0",
language = "English",
volume = "336",
pages = "215--221",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Research",
number = "6196",
}