TY - JOUR
T1 - Structural determinants of substrates and inhibitors
T2 - Probing glutamate transporters with 2,4-methanopyrrolidine-2,4-dicarboxylate
AU - Esslinger, C. Sean
AU - Koch, Hans P.
AU - Kavanaugh, Michael P.
AU - Philips, Dean P.
AU - Chamberlin, A. Richard
AU - Thompson, Charles M.
AU - Bridges, Richard J.
N1 - Funding Information:
Aelmowledgmeats: This work was funded in part by the NiH: NS27600 (ARC), NS30570 (RJB), and NS33270 (MPK). Support was also provided through an NSF instrument grant (CHE 9302468) for the purchase of the 400 MHz NMR used in this study. CSE was a postdoeto~ fellow of The American Heart Association (9604520S). References and Notes
PY - 1998/11
Y1 - 1998/11
N2 - Using an intramolecular [2+2] photocyclization, 2,4-methanopyrrolidine- 2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
AB - Using an intramolecular [2+2] photocyclization, 2,4-methanopyrrolidine- 2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
UR - http://www.scopus.com/inward/record.url?scp=0005761614&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00560-5
DO - 10.1016/S0960-894X(98)00560-5
M3 - Article
C2 - 9873684
AN - SCOPUS:0005761614
SN - 0960-894X
VL - 8
SP - 3101
EP - 3106
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 21
ER -