Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

Baisen Zeng, Tung Chung Mou, Tzanko I. Doukov, Andrea Steiner, Wenxi Yu, Makaia Papasergi-Scott, Gregory G. Tall, Franz Hagn, Stephen R. Sprang

Research output: Contribution to journalArticlepeer-review

Abstract

Zeng et al. use X-ray crystallography and small-angle scattering, in conjunction with NMR spectroscopy, to reveal the structure of and dynamics of the G protein chaperone and activator Ric-8A and probe its interaction with the G protein alpha subunit i1.

Original languageEnglish
Pages (from-to)1137-1147.e5
JournalStructure
Volume27
Issue number7
DOIs
StatePublished - Jul 2 2019

Keywords

  • X-ray crystallography
  • guanine nucleotide exchange factor
  • heteronuclear nuclear magnetic resonance
  • heterotrimeric G protein
  • molecular chaperone
  • protein dynamics
  • protein structure
  • small-angle X-ray scattering

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