Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

Baisen Zeng; Tung Chung Mou; Tzanko I. Doukov; Andrea Steiner; Wenxi Yu; Makaia Papasergi-Scott; Gregory G. Tall; Franz Hagn; Stephen R. Sprang

doi:10.1016/j.str.2019.04.013

Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

Baisen Zeng, Tung Chung Mou, Tzanko I. Doukov, Andrea Steiner, Wenxi Yu, Makaia Papasergi-Scott, Gregory G. Tall, Franz Hagn, Stephen R. Sprang

Division of Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Zeng et al. use X-ray crystallography and small-angle scattering, in conjunction with NMR spectroscopy, to reveal the structure of and dynamics of the G protein chaperone and activator Ric-8A and probe its interaction with the G protein alpha subunit i1.

Original language	English
Pages (from-to)	1137-1147.e5
Journal	Structure
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.str.2019.04.013
State	Published - Jul 2 2019

Keywords

X-ray crystallography
guanine nucleotide exchange factor
heteronuclear nuclear magnetic resonance
heterotrimeric G protein
molecular chaperone
protein dynamics
protein structure
small-angle X-ray scattering

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10.1016/j.str.2019.04.013

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title = "Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A",

abstract = "Zeng et al. use X-ray crystallography and small-angle scattering, in conjunction with NMR spectroscopy, to reveal the structure of and dynamics of the G protein chaperone and activator Ric-8A and probe its interaction with the G protein alpha subunit i1.",

keywords = "X-ray crystallography, guanine nucleotide exchange factor, heteronuclear nuclear magnetic resonance, heterotrimeric G protein, molecular chaperone, protein dynamics, protein structure, small-angle X-ray scattering",

author = "Baisen Zeng and Mou, \{Tung Chung\} and Doukov, \{Tzanko I.\} and Andrea Steiner and Wenxi Yu and Makaia Papasergi-Scott and Tall, \{Gregory G.\} and Franz Hagn and Sprang, \{Stephen R.\}",

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year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.str.2019.04.013",

language = "English",

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T1 - Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

AU - Zeng, Baisen

AU - Mou, Tung Chung

AU - Doukov, Tzanko I.

AU - Steiner, Andrea

AU - Yu, Wenxi

AU - Papasergi-Scott, Makaia

AU - Tall, Gregory G.

AU - Hagn, Franz

AU - Sprang, Stephen R.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Zeng et al. use X-ray crystallography and small-angle scattering, in conjunction with NMR spectroscopy, to reveal the structure of and dynamics of the G protein chaperone and activator Ric-8A and probe its interaction with the G protein alpha subunit i1.

AB - Zeng et al. use X-ray crystallography and small-angle scattering, in conjunction with NMR spectroscopy, to reveal the structure of and dynamics of the G protein chaperone and activator Ric-8A and probe its interaction with the G protein alpha subunit i1.

KW - X-ray crystallography

KW - guanine nucleotide exchange factor

KW - heteronuclear nuclear magnetic resonance

KW - heterotrimeric G protein

KW - molecular chaperone

KW - protein dynamics

KW - protein structure

KW - small-angle X-ray scattering

UR - https://www.scopus.com/pages/publications/85067889140

U2 - 10.1016/j.str.2019.04.013

DO - 10.1016/j.str.2019.04.013

M3 - Article

C2 - 31155309

AN - SCOPUS:85067889140

SN - 0969-2126

VL - 27

SP - 1137-1147.e5

JO - Structure

JF - Structure

IS - 7

ER -

Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

Abstract

Keywords

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