Structure-function correlates of glutamate-gated ion channels

K. B. Hansen, L. P. Wollmuth, S. F. Traynelis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Glutamate-gated ion channels participate in excitatory synaptic transmission in the nervous system as well as nonsynaptic communication between cells. The glutamate-gated ion channel family includes 18 gene products that form tetrameric transmembrane protein complexes. Glutamate-gated receptors are composed of multiple semiautonomous domains that share structural features with periplasmic amino acid-binding proteins and potassium channels. Each glutamate receptor contains both ligand recognition sites and an ion-permeable channel that spans the membrane. Specific components of the protein complex couple the conformational changes that result from agonist binding into opening of the permeation pore.

Original languageEnglish
Title of host publicationComprehensive Biophysics
PublisherElsevier Inc.
Pages4-30
Number of pages27
Volume6
ISBN (Print)9780080957180
DOIs
StatePublished - 2012

Keywords

  • AMPA
  • Excitatory neurotransmitter
  • Glutamate
  • Ionotropic glutamate receptor
  • Kainate
  • Ligand-gated ion channel
  • NMDA
  • Synaptic plasticity
  • Synaptic transmission

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