Structure-function correlates of glutamate-gated ion channels

K. B. Hansen; L. P. Wollmuth; S. F. Traynelis

doi:10.1016/B978-0-12-374920-8.00611-1

Structure-function correlates of glutamate-gated ion channels

K. B. Hansen
, L. P. Wollmuth
, S. F. Traynelis

Division of Biological and Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Glutamate-gated ion channels participate in excitatory synaptic transmission in the nervous system as well as nonsynaptic communication between cells. The glutamate-gated ion channel family includes 18 gene products that form tetrameric transmembrane protein complexes. Glutamate-gated receptors are composed of multiple semiautonomous domains that share structural features with periplasmic amino acid-binding proteins and potassium channels. Each glutamate receptor contains both ligand recognition sites and an ion-permeable channel that spans the membrane. Specific components of the protein complex couple the conformational changes that result from agonist binding into opening of the permeation pore.

Original language	English
Title of host publication	Comprehensive Biophysics
Publisher	Elsevier Inc.
Pages	4-30
Number of pages	27
Volume	6
ISBN (Print)	9780080957180
DOIs	https://doi.org/10.1016/B978-0-12-374920-8.00611-1
State	Published - 2012

Funding

This work was supported by the National Institutes of Health (Grants NS065371 (SFT), NS036654 (SFT), NS068464 (SFT), and MH066892 (LPW)), the Villum Kann Rasmussen Foundation (KBH), and the Lundbeck Foundation (KBH). The authors declare no competing interests.

Funder number
NS036654, NS065371, NS068464, MH066892

Keywords

AMPA
Excitatory neurotransmitter
Glutamate
Ionotropic glutamate receptor
Kainate
Ligand-gated ion channel
NMDA
Synaptic plasticity
Synaptic transmission

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10.1016/B978-0-12-374920-8.00611-1

Cite this

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title = "Structure-function correlates of glutamate-gated ion channels",

abstract = "Glutamate-gated ion channels participate in excitatory synaptic transmission in the nervous system as well as nonsynaptic communication between cells. The glutamate-gated ion channel family includes 18 gene products that form tetrameric transmembrane protein complexes. Glutamate-gated receptors are composed of multiple semiautonomous domains that share structural features with periplasmic amino acid-binding proteins and potassium channels. Each glutamate receptor contains both ligand recognition sites and an ion-permeable channel that spans the membrane. Specific components of the protein complex couple the conformational changes that result from agonist binding into opening of the permeation pore.",

keywords = "AMPA, Excitatory neurotransmitter, Glutamate, Ionotropic glutamate receptor, Kainate, Ligand-gated ion channel, NMDA, Synaptic plasticity, Synaptic transmission",

author = "Hansen, \{K. B.\} and Wollmuth, \{L. P.\} and Traynelis, \{S. F.\}",

note = "Funding Information: This work was supported by the National Institutes of Health (Grants NS065371 (SFT), NS036654 (SFT), NS068464 (SFT), and MH066892 (LPW)), the Villum Kann Rasmussen Foundation (KBH), and the Lundbeck Foundation (KBH). The authors declare no competing interests.",

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doi = "10.1016/B978-0-12-374920-8.00611-1",

language = "English",

isbn = "9780080957180",

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AU - Hansen, K. B.

AU - Wollmuth, L. P.

AU - Traynelis, S. F.

N1 - Funding Information: This work was supported by the National Institutes of Health (Grants NS065371 (SFT), NS036654 (SFT), NS068464 (SFT), and MH066892 (LPW)), the Villum Kann Rasmussen Foundation (KBH), and the Lundbeck Foundation (KBH). The authors declare no competing interests.

PY - 2012

Y1 - 2012

N2 - Glutamate-gated ion channels participate in excitatory synaptic transmission in the nervous system as well as nonsynaptic communication between cells. The glutamate-gated ion channel family includes 18 gene products that form tetrameric transmembrane protein complexes. Glutamate-gated receptors are composed of multiple semiautonomous domains that share structural features with periplasmic amino acid-binding proteins and potassium channels. Each glutamate receptor contains both ligand recognition sites and an ion-permeable channel that spans the membrane. Specific components of the protein complex couple the conformational changes that result from agonist binding into opening of the permeation pore.

AB - Glutamate-gated ion channels participate in excitatory synaptic transmission in the nervous system as well as nonsynaptic communication between cells. The glutamate-gated ion channel family includes 18 gene products that form tetrameric transmembrane protein complexes. Glutamate-gated receptors are composed of multiple semiautonomous domains that share structural features with periplasmic amino acid-binding proteins and potassium channels. Each glutamate receptor contains both ligand recognition sites and an ion-permeable channel that spans the membrane. Specific components of the protein complex couple the conformational changes that result from agonist binding into opening of the permeation pore.

KW - AMPA

KW - Excitatory neurotransmitter

KW - Glutamate

KW - Ionotropic glutamate receptor

KW - Kainate

KW - Ligand-gated ion channel

KW - NMDA

KW - Synaptic plasticity

KW - Synaptic transmission

UR - https://www.scopus.com/pages/publications/84882753479

U2 - 10.1016/B978-0-12-374920-8.00611-1

DO - 10.1016/B978-0-12-374920-8.00611-1

M3 - Chapter

AN - SCOPUS:84882753479

SN - 9780080957180

VL - 6

SP - 4

EP - 30

BT - Comprehensive Biophysics

PB - Elsevier Inc.

ER -

Structure-function correlates of glutamate-gated ion channels

Abstract

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Keywords

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