Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

Steven W. McDaniel; Charles M. Keyari; Kevin C. Rider; Nicholas R. Natale; Philippe Diaz

doi:10.1016/j.tetlet.2011.08.096

Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

Steven W. McDaniel, Charles M. Keyari, Kevin C. Rider, Nicholas R. Natale, Philippe Diaz

University of Montana

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)₂, JohnPhos as the catalyst and ligand, potassium carbonate as the base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.

Original language	English
Pages (from-to)	5656-5658
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2011.08.096
State	Published - Oct 26 2011

Keywords

Cross-coupling
Microwave
Palladium
Suzuki-Miyaura

Access to Document

10.1016/j.tetlet.2011.08.096

Cite this

@article{b0313917a7384da581b2adb645fb5663,

title = "Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions",

abstract = "A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)2, JohnPhos as the catalyst and ligand, potassium carbonate as the base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.",

keywords = "Cross-coupling, Microwave, Palladium, Suzuki-Miyaura",

author = "McDaniel, {Steven W.} and Keyari, {Charles M.} and Rider, {Kevin C.} and Natale, {Nicholas R.} and Philippe Diaz",

note = "Funding Information: This work was supported by NIH Grant P30-NS055022 . ",

year = "2011",

month = oct,

day = "26",

doi = "10.1016/j.tetlet.2011.08.096",

language = "English",

volume = "52",

pages = "5656--5658",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "43",

}

TY - JOUR

T1 - Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

AU - McDaniel, Steven W.

AU - Keyari, Charles M.

AU - Rider, Kevin C.

AU - Natale, Nicholas R.

AU - Diaz, Philippe

N1 - Funding Information: This work was supported by NIH Grant P30-NS055022 .

PY - 2011/10/26

Y1 - 2011/10/26

N2 - A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)2, JohnPhos as the catalyst and ligand, potassium carbonate as the base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.

AB - A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)2, JohnPhos as the catalyst and ligand, potassium carbonate as the base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.

KW - Cross-coupling

KW - Microwave

KW - Palladium

KW - Suzuki-Miyaura

UR - http://www.scopus.com/inward/record.url?scp=80053187924&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2011.08.096

DO - 10.1016/j.tetlet.2011.08.096

M3 - Article

AN - SCOPUS:80053187924

SN - 0040-4039

VL - 52

SP - 5656

EP - 5658

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this