Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

Steven W. McDaniel, Charles M. Keyari, Kevin C. Rider, Nicholas R. Natale, Philippe Diaz

Research output: Contribution to journalArticlepeer-review

Abstract

A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)2, JohnPhos as the catalyst and ligand, potassium carbonate as the base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.

Original languageEnglish
Pages (from-to)5656-5658
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number43
DOIs
StatePublished - Oct 26 2011

Keywords

  • Cross-coupling
  • Microwave
  • Palladium
  • Suzuki-Miyaura

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