TY - JOUR
T1 - Synthesis and biological activities of new heterocyclic aromatic retinoids
AU - Diaz, P.
AU - Michel, S.
AU - Stella, L.
AU - Charpentier, B.
PY - 1997/9/9
Y1 - 1997/9/9
N2 - A series of 3-aryl-2H-1-benzopyrancarboxylic acid derivatives was synthesized and evaluated as Retinoic Acid Receptor (RAR) agonists. By modifications of the 3-aryl group, we have obtained new retinoids exhibiting potent cellular differentiating activities and high affinities for RARs. Moreover, hydrogenation of the 2H-1-benzopyran ring led to the 3-(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl -naphthalen-2-yl)-3,4-dihydro-2H-1-benzopyran-7-yl carboxylic acid, characterized by a RARβ binding profile.
AB - A series of 3-aryl-2H-1-benzopyrancarboxylic acid derivatives was synthesized and evaluated as Retinoic Acid Receptor (RAR) agonists. By modifications of the 3-aryl group, we have obtained new retinoids exhibiting potent cellular differentiating activities and high affinities for RARs. Moreover, hydrogenation of the 2H-1-benzopyran ring led to the 3-(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl -naphthalen-2-yl)-3,4-dihydro-2H-1-benzopyran-7-yl carboxylic acid, characterized by a RARβ binding profile.
UR - http://www.scopus.com/inward/record.url?scp=0030984431&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(97)00405-8
DO - 10.1016/S0960-894X(97)00405-8
M3 - Article
AN - SCOPUS:0030984431
SN - 0960-894X
VL - 7
SP - 2289
EP - 2294
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -