Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Martyn J. Earle, Nigel D. Priestley

Research output: Contribution to journalArticlepeer-review

Abstract

A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

Original languageEnglish
Pages (from-to)2187-2192
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number17
DOIs
StatePublished - Sep 9 1997

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