Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Martyn J. Earle; Nigel D. Priestley

doi:10.1016/S0960-894X(97)00393-4

Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Martyn J. Earle, Nigel D. Priestley

Ohio State University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

Original language	English
Pages (from-to)	2187-2192
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	17
DOIs	https://doi.org/10.1016/S0960-894X(97)00393-4
State	Published - Sep 9 1997

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title = "Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796",

abstract = "A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.",

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AU - Earle, Martyn J.

AU - Priestley, Nigel D.

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Y1 - 1997/9/9

N2 - A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

AB - A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

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U2 - 10.1016/S0960-894X(97)00393-4

DO - 10.1016/S0960-894X(97)00393-4

M3 - Article

AN - SCOPUS:0030923583

SN - 0960-894X

VL - 7

SP - 2187

EP - 2192

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Abstract

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