Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Martyn J. Earle; Nigel D. Priestley

doi:10.1016/S0960-894X(97)00393-4

Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Martyn J. Earle, Nigel D. Priestley

Ohio State University

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12 Scopus citations

Abstract

A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

Original language	English
Pages (from-to)	2187-2192
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	17
DOIs	https://doi.org/10.1016/S0960-894X(97)00393-4
State	Published - Sep 9 1997

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10.1016/S0960-894X(97)00393-4

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title = "Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796",

abstract = "A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75\% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.",

author = "Earle, \{Martyn J.\} and Priestley, \{Nigel D.\}",

year = "1997",

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doi = "10.1016/S0960-894X(97)00393-4",

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TY - JOUR

T1 - Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

AU - Earle, Martyn J.

AU - Priestley, Nigel D.

PY - 1997/9/9

Y1 - 1997/9/9

N2 - A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

AB - A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

UR - https://www.scopus.com/pages/publications/0030923583

U2 - 10.1016/S0960-894X(97)00393-4

DO - 10.1016/S0960-894X(97)00393-4

M3 - Article

AN - SCOPUS:0030923583

SN - 0960-894X

VL - 7

SP - 2187

EP - 2192

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796

Abstract

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