@article{f3977a78004e4e9581b6cedfb9d6255b,
title = "Synthesis of a functionalized oxabicyclo[2.2.1]-heptene-based chemical library",
abstract = "The 7-oxabicyclo[2.2.1]heptene ring system is a common structural motif in many pharmacologically interesting molecules. We recognized the potential to employ this highly oxygenated and conformationally-restricted scaffold in diversity-oriented synthesis to generate a library of non-chiral but topologically complex compounds. Herein, we report the synthesis and biological evaluation of two 96-member tricyclic libraries containing the oxabicyclo[2.2.1]heptene framework using acetal formation as the key step.",
keywords = "Acetal, Antibacterial, Oxabicyclo[2.2.1]heptene",
author = "Luesse, \{Sarah B.\} and Gregg Wells and Jeanne Miller and Erin Bolstad and Bergmeier, \{Stephen C.\} and McMills, \{Mark C.\} and Priestley, \{Nigel D.\} and Wright, \{Dennis L.\}",
year = "2012",
month = jan,
doi = "10.2174/138620712798280835",
language = "English",
volume = "15",
pages = "81--89",
journal = "Combinatorial Chemistry and High Throughput Screening",
issn = "1386-2073",
publisher = "Bentham Science Publishers",
number = "1",
}