Synthesis of bridged bicyclic β-trifluoroacetoxy β-trifluoromethyl α-amino acid derivatives by an original dakin-west/Diels-Alder tandem sequence

Thierry Cufos, Philippe Diaz, Lucien Stella

Research output: Contribution to journalArticlepeer-review

Abstract

The reaction of hippuric acid with trifluoroacetic anhydride in the presence of cyclopentadiene affords useful bicyclic α-amino acid derivatives bearing β-trifluoroacetoxy and β-trifluoromethyl groups.

Original languageEnglish
Pages (from-to)101-102
Number of pages2
JournalSynlett
Volume1995
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • 2-phenyl-5-oxazolone
  • Dakin-West reaction
  • Diels-Alder cycloaddition
  • tandem sequence
  • β-trifluoromethyl α-amino acids

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