Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew

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Abstract

Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia. The fungus is hyphomyceteous and, when grown in a semi-synthetic liquid medium, produced taxol and related compounds. Taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol. Both [1- 14C]acetic acid and L-[U-14C]phenylalanine served as precursors of [14C]taxol in fungal cultures. No taxol was detected in zero-time cultures or in the small agar plugs used to inoculate the culture flasks.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalScience
Volume260
Issue number5105
DOIs
StatePublished - 1993

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