Tetraethyl orthosilicate-based hydrogels for drug delivery—effects of their nanoparticulate structure on release properties

Bogdan A. Serban, Emma Barrett-Catton, Monica A. Serban

Research output: Contribution to journalArticlepeer-review

Abstract

Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications.

Original languageEnglish
Article number38
Pages (from-to)1-10
Number of pages10
JournalGels
Volume6
Issue number4
DOIs
StatePublished - Dec 2020

Keywords

  • Drug release
  • Nanoparticles
  • Tetraethyl orthosilicate
  • Thixogel

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