Tetraethyl orthosilicate-based hydrogels for drug delivery—effects of their nanoparticulate structure on release properties

Bogdan A. Serban; Emma Barrett-Catton; Monica A. Serban

doi:10.3390/gels6040038

Tetraethyl orthosilicate-based hydrogels for drug delivery—effects of their nanoparticulate structure on release properties

Bogdan A. Serban
, Emma Barrett-Catton
, Monica A. Serban

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications.

Original language	English
Article number	38
Pages (from-to)	1-10
Number of pages	10
Journal	Gels
Volume	6
Issue number	4
DOIs	https://doi.org/10.3390/gels6040038
State	Published - Dec 2020

Funding

Funding: This project was funded by a 2019 Center for Translational Medicine Summer Undergraduate Research Internship at University of Montana, awarded to Emma Barrett-Catton and the Serban Lab.

Keywords

Drug release
Nanoparticles
Tetraethyl orthosilicate
Thixogel

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10.3390/gels6040038

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title = "Tetraethyl orthosilicate-based hydrogels for drug delivery—effects of their nanoparticulate structure on release properties",

abstract = "Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications.",

keywords = "Drug release, Nanoparticles, Tetraethyl orthosilicate, Thixogel",

author = "Serban, \{Bogdan A.\} and Emma Barrett-Catton and Serban, \{Monica A.\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = dec,

doi = "10.3390/gels6040038",

language = "English",

volume = "6",

pages = "1--10",

journal = "Gels",

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TY - JOUR

T1 - Tetraethyl orthosilicate-based hydrogels for drug delivery—effects of their nanoparticulate structure on release properties

AU - Serban, Bogdan A.

AU - Barrett-Catton, Emma

AU - Serban, Monica A.

PY - 2020/12

Y1 - 2020/12

N2 - Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications.

AB - Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications.

KW - Drug release

KW - Nanoparticles

KW - Tetraethyl orthosilicate

KW - Thixogel

UR - https://www.scopus.com/pages/publications/85094604648

U2 - 10.3390/gels6040038

DO - 10.3390/gels6040038

M3 - Article

AN - SCOPUS:85094604648

SN - 2310-2861

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JF - Gels

IS - 4

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ER -

Tetraethyl orthosilicate-based hydrogels for drug delivery—effects of their nanoparticulate structure on release properties

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