The association of urinary 5-hydroxyindoleacetic acid and vanillylmandelic acid in patients with generalized anxiety

M. J. Garvey, R. Noyes, C. Woodman, C. Laukes

Research output: Contribution to journalArticlepeer-review

Abstract

There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with generalized anxiety disorder. There was a significant association between urinary levels of 5-HIAA and VMA: r = 0.79; p = 0.0001. Possible implications of this finding are discussed.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalNeuropsychobiology
Volume31
Issue number1
DOIs
StatePublished - 1995

Keywords

  • 5-Hydroxyindoleacetic acid
  • Generalized anxiety disorder
  • Vanillylmandelic acid

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