The Biological Significance of Trogocytosis

Deborah Agbakwuru, Scott A. Wetzel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Trogocytosis is the intercellular transfer of membrane and membrane-associated proteins between cells. Trogocytosis is an underappreciated phenomenon that has historically routinely been dismissed as an artefact. With a greater understanding of the process and the implications it has on biological systems, trogocytosis has the potential to become a paradigm changer. The presence on a cell of molecules they don’t endogenously express can alter the biological activity of the cell and could also lead to the acquisition of new functions. To better appreciate this phenomenon, it is important to understand how these intercellular membrane exchanges influence the function and activity of the donor and the recipient cells. In this chapter, we will examine how the molecules acquired by trogocytosis influence the biology of a variety of systems including mammalian fertilization, treatment of hemolytic disease of the newborn, viral and parasitic infections, cancer immunotherapy, and immune modulation.

Original languageEnglish
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Science and Business Media Deutschland GmbH
Pages87-129
Number of pages43
DOIs
StatePublished - 2024

Publication series

NameResults and Problems in Cell Differentiation
Volume73
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

Keywords

  • Cancer immunotherapy
  • Embryonic development
  • Fertilization
  • Intercellular transfer
  • Transendocytosis
  • Trogocytosis
  • Trogocytosis-mediated signaling

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