The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde

Jared K. Nelson, Brendan Twamley, Trinidad J. Villalobos, Nicholas R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

Nucleophilic addition of alkyl- and aryl-zinc reagents to a C(4) functionalized isoxazolyl aldehyde proceeded effectively with high enantioselectivity (85-94% ee). The amino alcohol catalyst (S)-2-piperidinyl-1,1,2-triphenyl ethanol (10) afforded the (R)-product 2b, as established by X-ray crystallography.

Original languageEnglish
Pages (from-to)5957-5960
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number41
DOIs
StatePublished - Oct 6 2008

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