@article{de5a6d90263849cfa78c6ad2003ea2ee,
title = "The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde",
abstract = "Nucleophilic addition of alkyl- and aryl-zinc reagents to a C(4) functionalized isoxazolyl aldehyde proceeded effectively with high enantioselectivity (85-94% ee). The amino alcohol catalyst (S)-2-piperidinyl-1,1,2-triphenyl ethanol (10) afforded the (R)-product 2b, as established by X-ray crystallography.",
author = "Nelson, {Jared K.} and Brendan Twamley and Villalobos, {Trinidad J.} and Natale, {Nicholas R.}",
note = "Funding Information: The authors thank NIH for grants NS038444(NN), P20RR015583(NN), P20RR16454(JKN), the Fraternal Order of Eagles Alzheimer{\textquoteright}s Fund (NN), and the Malcolm and Carol Renfrew Scholarship (JKN). The Bruker (Siemens) SMART APEX diffraction facility was established at the University of Idaho with the assistance of the NSF-EPSCoR program and the M. J. Murdock Charitable Trust, Vancouver, WA, USA. We thank Rakesh Kumar and Shikha Sharma for technical assistance. ",
year = "2008",
month = oct,
day = "6",
doi = "10.1016/j.tetlet.2008.07.169",
language = "English",
volume = "49",
pages = "5957--5960",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd",
number = "41",
}