The complete mitochondrial DNA genome of an unknown hominin from southern Siberia

Johannes Krause; Qiaomei Fu; Jeffrey M. Good; Bence Viola; Michael V. Shunkov; Anatoli P. Derevianko; Svante Pääbo

doi:10.1038/nature08976

The complete mitochondrial DNA genome of an unknown hominin from southern Siberia

Johannes Krause, Qiaomei Fu, Jeffrey M. Good, Bence Viola, Michael V. Shunkov, Anatoli P. Derevianko, Svante Pääbo

Biological Sciences

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551 Scopus citations

Abstract

With the exception of Neanderthals, from which DNA sequences of numerous individuals have now been determined¹, the number and genetic relationships of other hominin lineages are largely unknown. Here we report a complete mitochondrial (mt) DNA sequence retrieved from a bone excavated in 2008 in Denisova Cave in the Altai Mountains in southern Siberia. It represents a hitherto unknown type of hominin mtDNA that shares a common ancestor with anatomically modern human and Neanderthal mtDNAs about 1.0 million years ago. This indicates that it derives from a hominin migration out of Africa distinct from that of the ancestors of Neanderthals and of modern humans. The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans^2-4.

Original language	English
Pages (from-to)	894-897
Number of pages	4
Journal	Nature
Volume	464
Issue number	7290
DOIs	https://doi.org/10.1038/nature08976
State	Published - Apr 8 2010

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title = "The complete mitochondrial DNA genome of an unknown hominin from southern Siberia",

abstract = "With the exception of Neanderthals, from which DNA sequences of numerous individuals have now been determined1, the number and genetic relationships of other hominin lineages are largely unknown. Here we report a complete mitochondrial (mt) DNA sequence retrieved from a bone excavated in 2008 in Denisova Cave in the Altai Mountains in southern Siberia. It represents a hitherto unknown type of hominin mtDNA that shares a common ancestor with anatomically modern human and Neanderthal mtDNAs about 1.0 million years ago. This indicates that it derives from a hominin migration out of Africa distinct from that of the ancestors of Neanderthals and of modern humans. The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans2-4.",

author = "Johannes Krause and Qiaomei Fu and Good, {Jeffrey M.} and Bence Viola and Shunkov, {Michael V.} and Derevianko, {Anatoli P.} and Svante P{\"a}{\"a}bo",

note = "Funding Information: Acknowledgements We thank A. W. Briggs, K. Finstermeier, R. E. Green, J.-J. Hublin, M. Kircher, A. I. Krivoshapkin, T. Maricic, M. Stoneking, A. Tsybonkov, L. Vigilant and V. Wiebe for comments, M. Meyer, the MPI-EVA sequencing group and M. Kircher for technical support, and the Presidential Innovation Fund of the Max Planck Society for financial support. J.M.G. was supported during this research by an NSF international postdoctoral fellowship (OISE-0754461).",

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T1 - The complete mitochondrial DNA genome of an unknown hominin from southern Siberia

AU - Krause, Johannes

AU - Fu, Qiaomei

AU - Good, Jeffrey M.

AU - Viola, Bence

AU - Shunkov, Michael V.

AU - Derevianko, Anatoli P.

AU - Pääbo, Svante

N1 - Funding Information: Acknowledgements We thank A. W. Briggs, K. Finstermeier, R. E. Green, J.-J. Hublin, M. Kircher, A. I. Krivoshapkin, T. Maricic, M. Stoneking, A. Tsybonkov, L. Vigilant and V. Wiebe for comments, M. Meyer, the MPI-EVA sequencing group and M. Kircher for technical support, and the Presidential Innovation Fund of the Max Planck Society for financial support. J.M.G. was supported during this research by an NSF international postdoctoral fellowship (OISE-0754461).

PY - 2010/4/8

Y1 - 2010/4/8

N2 - With the exception of Neanderthals, from which DNA sequences of numerous individuals have now been determined1, the number and genetic relationships of other hominin lineages are largely unknown. Here we report a complete mitochondrial (mt) DNA sequence retrieved from a bone excavated in 2008 in Denisova Cave in the Altai Mountains in southern Siberia. It represents a hitherto unknown type of hominin mtDNA that shares a common ancestor with anatomically modern human and Neanderthal mtDNAs about 1.0 million years ago. This indicates that it derives from a hominin migration out of Africa distinct from that of the ancestors of Neanderthals and of modern humans. The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans2-4.

AB - With the exception of Neanderthals, from which DNA sequences of numerous individuals have now been determined1, the number and genetic relationships of other hominin lineages are largely unknown. Here we report a complete mitochondrial (mt) DNA sequence retrieved from a bone excavated in 2008 in Denisova Cave in the Altai Mountains in southern Siberia. It represents a hitherto unknown type of hominin mtDNA that shares a common ancestor with anatomically modern human and Neanderthal mtDNAs about 1.0 million years ago. This indicates that it derives from a hominin migration out of Africa distinct from that of the ancestors of Neanderthals and of modern humans. The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans2-4.

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The complete mitochondrial DNA genome of an unknown hominin from southern Siberia

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