The furan route to tropolones: Probing the antiproliferative effects of β-thujaplicin analogs

E. Zachary Oblak, Erin S.D. Bolstad, Sophia N. Ononye, Nigel D. Priestley, M. Kyle Hadden, Dennis L. Wright

Research output: Contribution to journalArticlepeer-review

Abstract

A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.

Original languageEnglish
Pages (from-to)8597-8604
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number43
DOIs
StatePublished - Nov 21 2012

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