The furan route to tropolones: Probing the antiproliferative effects of β-thujaplicin analogs

E. Zachary Oblak; Erin S.D. Bolstad; Sophia N. Ononye; Nigel D. Priestley; M. Kyle Hadden; Dennis L. Wright

doi:10.1039/c2ob26553b

The furan route to tropolones: Probing the antiproliferative effects of β-thujaplicin analogs

E. Zachary Oblak
, Erin S.D. Bolstad
, Sophia N. Ononye
, Nigel D. Priestley
, M. Kyle Hadden
, Dennis L. Wright

Chemistry and Biochemistry

University of Connecticut
Promiliad Biopharma

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.

Original language	English
Pages (from-to)	8597-8604
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	43
DOIs	https://doi.org/10.1039/c2ob26553b
State	Published - Nov 21 2012

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10.1039/c2ob26553b

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abstract = "A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.",

author = "\{Zachary Oblak\}, E. and Bolstad, \{Erin S.D.\} and Ononye, \{Sophia N.\} and Priestley, \{Nigel D.\} and \{Kyle Hadden\}, M. and Wright, \{Dennis L.\}",

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AU - Zachary Oblak, E.

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AU - Ononye, Sophia N.

AU - Priestley, Nigel D.

AU - Kyle Hadden, M.

AU - Wright, Dennis L.

PY - 2012/11/21

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AB - A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.

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U2 - 10.1039/c2ob26553b

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JO - Organic and Biomolecular Chemistry

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ER -

The furan route to tropolones: Probing the antiproliferative effects of β-thujaplicin analogs

Abstract

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