The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance

Swathy Krishna; John C. Quindry; Rudy J. Valentine; Joshua T. Selsby

doi:10.1249/JES.0000000000000328

The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance

Swathy Krishna, John C. Quindry, Rudy J. Valentine, Joshua T. Selsby

Integrative Physiology and Athletic Training

Iowa State University

Research output: Contribution to journal › Article › peer-review

Abstract

Duchenne muscular dystrophy (DMD), caused by deficiency of functional dystrophin protein, is a fatal, progressive muscle disease that frequently includes metabolic dysregulation. Herein, we explore the physiologic consequences of dystrophin deficiency within the context of obesity and insulin resistance. We hypothesized that dystrophin deficiency increases the frequency of insulin resistance, and insulin resistance potentiates muscle pathology caused by dystrophin deficiency.

Original language	English
Pages (from-to)	31-38
Number of pages	8
Journal	Exercise and Sport Sciences Reviews
Volume	52
Issue number	1
DOIs	https://doi.org/10.1249/JES.0000000000000328
State	Published - Jan 1 2024

Keywords

dyslipidemia
insulin signaling
mdx
metabolism
obesity
Humans
Insulin Resistance
Muscle, Skeletal/metabolism
Muscular Dystrophy, Duchenne
Dystrophin/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1249/JES.0000000000000328

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title = "The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance",

abstract = "Duchenne muscular dystrophy (DMD), caused by deficiency of functional dystrophin protein, is a fatal, progressive muscle disease that frequently includes metabolic dysregulation. Herein, we explore the physiologic consequences of dystrophin deficiency within the context of obesity and insulin resistance. We hypothesized that dystrophin deficiency increases the frequency of insulin resistance, and insulin resistance potentiates muscle pathology caused by dystrophin deficiency.",

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AU - Valentine, Rudy J.

AU - Selsby, Joshua T.

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AB - Duchenne muscular dystrophy (DMD), caused by deficiency of functional dystrophin protein, is a fatal, progressive muscle disease that frequently includes metabolic dysregulation. Herein, we explore the physiologic consequences of dystrophin deficiency within the context of obesity and insulin resistance. We hypothesized that dystrophin deficiency increases the frequency of insulin resistance, and insulin resistance potentiates muscle pathology caused by dystrophin deficiency.

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KW - insulin signaling

KW - mdx

KW - metabolism

KW - obesity

KW - Humans

KW - Insulin Resistance

KW - Muscle, Skeletal/metabolism

KW - Muscular Dystrophy, Duchenne

KW - Dystrophin/metabolism

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JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 1

ER -

The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance

Abstract

Keywords

UN SDGs

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