The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance

Swathy Krishna, John C. Quindry, Rudy J. Valentine, Joshua T. Selsby

Research output: Contribution to journalArticlepeer-review


Duchenne muscular dystrophy (DMD), caused by deficiency of functional dystrophin protein, is a fatal, progressive muscle disease that frequently includes metabolic dysregulation. Herein, we explore the physiologic consequences of dystrophin deficiency within the context of obesity and insulin resistance. We hypothesized that dystrophin deficiency increases the frequency of insulin resistance, and insulin resistance potentiates muscle pathology caused by dystrophin deficiency.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalExercise and Sport Sciences Reviews
Issue number1
StatePublished - Jan 1 2024


  • dyslipidemia
  • insulin signaling
  • mdx
  • metabolism
  • obesity
  • Humans
  • Insulin Resistance
  • Muscle, Skeletal/metabolism
  • Muscular Dystrophy, Duchenne
  • Dystrophin/metabolism


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