Abstract
Duchenne muscular dystrophy (DMD), caused by deficiency of functional dystrophin protein, is a fatal, progressive muscle disease that frequently includes metabolic dysregulation. Herein, we explore the physiologic consequences of dystrophin deficiency within the context of obesity and insulin resistance. We hypothesized that dystrophin deficiency increases the frequency of insulin resistance, and insulin resistance potentiates muscle pathology caused by dystrophin deficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 31-38 |
| Number of pages | 8 |
| Journal | Exercise and Sport Sciences Reviews |
| Volume | 52 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2024 |
Funding
S.K. was funded in part by MDA grant 962344 awarded to J.T.S. and R.J.V. The authors have no conflicts to disclose.
| Funder number |
|---|
| 962344 |
Keywords
- dyslipidemia
- insulin signaling
- mdx
- metabolism
- obesity
- Humans
- Insulin Resistance
- Muscle, Skeletal/metabolism
- Muscular Dystrophy, Duchenne
- Dystrophin/metabolism
