Abstract
Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate cyclases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.
Original language | English |
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Pages (from-to) | 205-210 |
Number of pages | 6 |
Journal | Trends in Pharmacological Sciences |
Volume | 20 |
Issue number | 5 |
DOIs | |
State | Published - May 1 1999 |