The isoxazole as a linchpin for molecules that target folded DNA conformations: Selective lateral lithiation and palladation

Xiaochun Han; Chun Li; Kevin C. Rider; Alex Blumenfeld; Brendan Twamley; N. R. Natale

doi:10.1016/S0040-4039(02)01845-2

The isoxazole as a linchpin for molecules that target folded DNA conformations: Selective lateral lithiation and palladation

Xiaochun Han, Chun Li, Kevin C. Rider, Alex Blumenfeld, Brendan Twamley, N. R. Natale

University of Idaho

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

3-(10′-Halo-9′-anthracenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl esters served as a useful scaffold for highly efficient lateral metalation at the C(5), and Suzuki-Fu palladium catalyzed cross coupling at the C(10′).

Original language	English
Pages (from-to)	7673-7677
Number of pages	5
Journal	Tetrahedron Letters
Volume	43
Issue number	43
DOIs	https://doi.org/10.1016/S0040-4039(02)01845-2
State	Published - Oct 21 2002

Funding

We would like to thank the University of Idaho Research Council, and the National Cancer Institute for financial support. We thank Drs. Ron Crawford and Andrzej J. Paszczynski of the Environmental Biotechnology Institute, University of Idaho, for use of their computational facility. Dr. Dan Zaharevitz assisted us with the COMPARE calculation and interpretation. N.R.N. thanks the National Institute of Neurological Disease and Stroke for Grant 2R15-NS38444. X.H., C.L. and K.C.R. acknowledge the Malcolm and Carol Renfrew Scholarship Endowment, University of Idaho. We would like to thank Professor Kin Shing Chan of The Chinese University of Hong Kong for helpful discussions.

Funder number
2R15-NS38444

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10.1016/S0040-4039(02)01845-2

Cite this

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title = "The isoxazole as a linchpin for molecules that target folded DNA conformations: Selective lateral lithiation and palladation",

abstract = "3-(10′-Halo-9′-anthracenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl esters served as a useful scaffold for highly efficient lateral metalation at the C(5), and Suzuki-Fu palladium catalyzed cross coupling at the C(10′).",

author = "Xiaochun Han and Chun Li and Rider, \{Kevin C.\} and Alex Blumenfeld and Brendan Twamley and Natale, \{N. R.\}",

note = "Funding Information: We would like to thank the University of Idaho Research Council, and the National Cancer Institute for financial support. We thank Drs. Ron Crawford and Andrzej J. Paszczynski of the Environmental Biotechnology Institute, University of Idaho, for use of their computational facility. Dr. Dan Zaharevitz assisted us with the COMPARE calculation and interpretation. N.R.N. thanks the National Institute of Neurological Disease and Stroke for Grant 2R15-NS38444. X.H., C.L. and K.C.R. acknowledge the Malcolm and Carol Renfrew Scholarship Endowment, University of Idaho. We would like to thank Professor Kin Shing Chan of The Chinese University of Hong Kong for helpful discussions.",

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month = oct,

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doi = "10.1016/S0040-4039(02)01845-2",

language = "English",

volume = "43",

pages = "7673--7677",

journal = "Tetrahedron Letters",

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T1 - The isoxazole as a linchpin for molecules that target folded DNA conformations

T2 - Selective lateral lithiation and palladation

AU - Han, Xiaochun

AU - Li, Chun

AU - Rider, Kevin C.

AU - Blumenfeld, Alex

AU - Twamley, Brendan

AU - Natale, N. R.

N1 - Funding Information: We would like to thank the University of Idaho Research Council, and the National Cancer Institute for financial support. We thank Drs. Ron Crawford and Andrzej J. Paszczynski of the Environmental Biotechnology Institute, University of Idaho, for use of their computational facility. Dr. Dan Zaharevitz assisted us with the COMPARE calculation and interpretation. N.R.N. thanks the National Institute of Neurological Disease and Stroke for Grant 2R15-NS38444. X.H., C.L. and K.C.R. acknowledge the Malcolm and Carol Renfrew Scholarship Endowment, University of Idaho. We would like to thank Professor Kin Shing Chan of The Chinese University of Hong Kong for helpful discussions.

PY - 2002/10/21

Y1 - 2002/10/21

N2 - 3-(10′-Halo-9′-anthracenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl esters served as a useful scaffold for highly efficient lateral metalation at the C(5), and Suzuki-Fu palladium catalyzed cross coupling at the C(10′).

AB - 3-(10′-Halo-9′-anthracenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl esters served as a useful scaffold for highly efficient lateral metalation at the C(5), and Suzuki-Fu palladium catalyzed cross coupling at the C(10′).

UR - https://www.scopus.com/pages/publications/0037152345

U2 - 10.1016/S0040-4039(02)01845-2

DO - 10.1016/S0040-4039(02)01845-2

M3 - Article

AN - SCOPUS:0037152345

SN - 0040-4039

VL - 43

SP - 7673

EP - 7677

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

The isoxazole as a linchpin for molecules that target folded DNA conformations: Selective lateral lithiation and palladation

Abstract

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