@article{18a7676556994f5880515a3056865d77,
title = "The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor",
abstract = "Little is known about how the odor specificities of olfactory neurons are generated, a process essential to olfactory coding. We have found that neuronal identity relies on the abnormal chemosensory jump 6 (acj6) gene, originally identified by a defect in olfactory behavior. Physiological analysis of individual olfactory neurons shows that in acj6 mutants, a subset of neurons acquires a different odorant response profile. Certain other neurons do not respond to any tested odors in acj6. Molecular analysis of acj6 shows that it encodes a POU-domain transcription factor expressed in olfactory neurons. Our data suggest that the odor response spectrum of an olfactory neuron, and perhaps the choice of receptor genes, is determined through a process requiring the action of Acj6.",
author = "Clyne, {Peter J.} and Certel, {Sarah J.} and {De Bruyne}, Marien and Lina Zaslavsky and Johnson, {Wayne A.} and Carlson, {John R.}",
note = "Funding Information: We thank E. Vallen, J. Paxson-Jankovsky, and M. Grams for assistance with the genomic walk; M. Grams and J. Ratchford for assistance with the mutageneses; C. Horak for assistance with RT–PCR; S. Thor and K. J. Coker for antibody purification advice; and A. Chinn, K. Certel, and members of the Carlson and Johnson labs for support and helpful discussions. This work was supported by an NSF predoctoral fellowship grant to P. J. C., an NIH Genetics predoctoral training program grant to S. C., an HFSP Fellowship to M. deB, and an NIH grant (DC-02174) to J. R. C. ",
year = "1999",
month = feb,
doi = "10.1016/S0896-6273(00)81094-6",
language = "English",
volume = "22",
pages = "339--347",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}