The preparation of intercalating isoxazoles via a nitrile oxide cycloaddition

Michael D. Mosher, Nicholas R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

Pyridinium chlorochromate oxidation of 9‐methylacridine 2 affords the corresponding aldehyde 3 in good yield. Conversion of the aldehyde to the hydroximinoyl chloride 5a was accomplished via reaction of the corresponding oxime with N‐chlorosuccinimide. Dipolar addition to the enamine of ethylacetoacetate provided the corresponding isoxazoles 1 in good yield.

Original languageEnglish
Pages (from-to)779-781
Number of pages3
JournalJournal of Heterocyclic Chemistry
Volume32
Issue number3
DOIs
StatePublished - 1995

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