The preparation of perfluoroaryl substituted isoxazoles via nucleophilic aromatic substitution with lithioalkylisoxazoles

Xiongbing Xia, Gary Knerr, N. R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

The lithioalkylisoxazoles obtained from C‐5 lateral metalation of alkylisoxazoles, 1, add to hexafluorobenzene. When the C‐4 substituent was an electron withdrawing tertiary amide moiety, the yields were highest for mono‐perfluoroarylation to give 5‐pentafluorophenylmethylisoxazoles, 2.

Original languageEnglish
Pages (from-to)1297-1299
Number of pages3
JournalJournal of Heterocyclic Chemistry
Volume29
Issue number5
DOIs
StatePublished - 1992

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