The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer

K. D. Sugden, D. M. Stearns

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The role that high valent chromium intermediates play in the oxidative DNA damage produced by the human carcinogen chromate Cr(VI) is of increasing interest for establishing a mechanism of genotoxicity and mutagenicity for this metal. In this review, the authors summarize experimental evidence for the formation of high valent chromium complexes (primarily the +5 oxidation state) and radical species from the reductive metabolism of Cr(VI). A case is made for a direct- or metal-mediated pathway by high valent chromium to initiate oxidative DNA damage, although the role of radical species in this oxidative process cannot be ruled out.

    Original languageEnglish
    Pages (from-to)215-230
    Number of pages16
    JournalJournal of Environmental Pathology, Toxicology and Oncology
    Volume19
    Issue number3
    StatePublished - 2000

    Keywords

    • Carcinogenesis
    • Chromium
    • Cr(V)
    • Mutagenesis
    • Oxidative DNA damage
    • Radicals

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