@article{2c33d4e4aab84b07949420a3e8f47816,
title = "The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer",
abstract = "The role that high valent chromium intermediates play in the oxidative DNA damage produced by the human carcinogen chromate Cr(VI) is of increasing interest for establishing a mechanism of genotoxicity and mutagenicity for this metal. In this review, the authors summarize experimental evidence for the formation of high valent chromium complexes (primarily the +5 oxidation state) and radical species from the reductive metabolism of Cr(VI). A case is made for a direct- or metal-mediated pathway by high valent chromium to initiate oxidative DNA damage, although the role of radical species in this oxidative process cannot be ruled out.",
keywords = "Carcinogenesis, Chromium, Cr(V), Mutagenesis, Oxidative DNA damage, Radicals",
author = "Sugden, \{K. D.\} and Stearns, \{D. M.\}",
year = "2000",
language = "English",
volume = "19",
pages = "215--230",
journal = "Journal of Environmental Pathology, Toxicology and Oncology",
issn = "0731-8898",
publisher = "Begell House Inc.",
number = "3",
}
