The structure, catalytic mechanism and regulation of adenylyl cyclase

John J.G. Tesmer; Stephen R. Sprang

doi:10.1016/S0959-440X(98)80090-0

The structure, catalytic mechanism and regulation of adenylyl cyclase

John J.G. Tesmer
, Stephen R. Sprang

Division of Biological and Biomedical Sciences

Howard Hughes Medical Institute

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

The recent structure determinations of the mammalian effector enzyme adenylyl cyclase reveal the structure of its catalytic core, provide new insights into its catalytic mechanism and suggest how diverse signaling molecules regulate its activity.

Original language	English
Pages (from-to)	713-719
Number of pages	7
Journal	Current Opinion in Structural Biology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/S0959-440X(98)80090-0
State	Published - Dec 1998

Funding

The authors would like to thank Roger Sunahara and Carmen Dessauer for their critical reading of the manuscript, and Lothar Esser for assistance in preparing the figures. SRS is supported by National Institutes of Health grant DK46371 and Welch Foundation grant I-1229.

Funder number
R01DK046371
I-1229

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10.1016/S0959-440X(98)80090-0

Cite this

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title = "The structure, catalytic mechanism and regulation of adenylyl cyclase",

abstract = "The recent structure determinations of the mammalian effector enzyme adenylyl cyclase reveal the structure of its catalytic core, provide new insights into its catalytic mechanism and suggest how diverse signaling molecules regulate its activity.",

author = "Tesmer, \{John J.G.\} and Sprang, \{Stephen R.\}",

note = "Funding Information: The authors would like to thank Roger Sunahara and Carmen Dessauer for their critical reading of the manuscript, and Lothar Esser for assistance in preparing the figures. SRS is supported by National Institutes of Health grant DK46371 and Welch Foundation grant I-1229.",

year = "1998",

month = dec,

doi = "10.1016/S0959-440X(98)80090-0",

language = "English",

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pages = "713--719",

journal = "Current Opinion in Structural Biology",

issn = "0959-440X",

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T1 - The structure, catalytic mechanism and regulation of adenylyl cyclase

AU - Tesmer, John J.G.

AU - Sprang, Stephen R.

N1 - Funding Information: The authors would like to thank Roger Sunahara and Carmen Dessauer for their critical reading of the manuscript, and Lothar Esser for assistance in preparing the figures. SRS is supported by National Institutes of Health grant DK46371 and Welch Foundation grant I-1229.

PY - 1998/12

Y1 - 1998/12

N2 - The recent structure determinations of the mammalian effector enzyme adenylyl cyclase reveal the structure of its catalytic core, provide new insights into its catalytic mechanism and suggest how diverse signaling molecules regulate its activity.

AB - The recent structure determinations of the mammalian effector enzyme adenylyl cyclase reveal the structure of its catalytic core, provide new insights into its catalytic mechanism and suggest how diverse signaling molecules regulate its activity.

UR - https://www.scopus.com/pages/publications/0032412405

U2 - 10.1016/S0959-440X(98)80090-0

DO - 10.1016/S0959-440X(98)80090-0

M3 - Article

C2 - 9914249

AN - SCOPUS:0032412405

SN - 0959-440X

VL - 8

SP - 713

EP - 719

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

IS - 6

ER -

The structure, catalytic mechanism and regulation of adenylyl cyclase

Abstract

Funding

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