Thyroxine-binding globulin, peripheral deiodinase activity, and thyroid autoantibody status in association of phthalates and phenolic compounds with thyroid hormones in adult population

Sohyeon Choi, Min Joo Kim, Young Joo Park, Sunmi Kim, Kyungho Choi, Gi Jeong Cheon, Yoon Hee Cho, Hye Li Jeon, Jiyoung Yoo, Jeongim Park

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30 Scopus citations

Abstract

Exposure to consumer chemicals such as phthalates and phenolic compounds has been associated with thyroid hormone disruption in humans. However, information related to factors that may influence such associations, e.g., transport and activation of the hormones, and autoimmunity status, is limited. In the present study, we employed a subpopulation of adults (n = 1,254) who participated in the Korean National Environmental Health Survey (KoNEHS) 2015–2017, and associated urinary concentrations of major phthalate metabolites, bisphenol A (BPA), and parabens, with thyroid hormone-related measures, including free and total T3 and T4, TSH, thyroxine-binding globulin (TBG), calculated peripheral deiodinase (DIO) activity, and thyroid autoantibodies of thyroperoxidase (TPO) and thyroglobulin (Tg). Phthalate metabolites were negatively associated with total T4 and free T3, and positively associated with total T3. These observations could be explained by TBG levels and calculated peripheral DIO activity that were positively associated with phthalates exposure. In contrast, BPA was positively associated with total T4 and negatively associated with total T3, without any changes in TBG concentration. Serum TPO and Tg antibodies were not associated with urinary phthalate metabolites and BPA. However, thyroid autoantibody status appeared to modulate the association of some phthalates with thyroid hormones. For parabens, little to negligible association was observed. The results of our observation show potential underlying mechanisms of phthalates-induced thyroid hormone disruption, and suggests the importance of consideration of thyroid autoimmunity status in association studies for thyroid disrupting chemicals.

Original languageEnglish
Article number105783
JournalEnvironment International
Volume140
DOIs
StatePublished - Jul 2020

Funding

This study was supported by a grant from the National Institute of Environmental Research funded by the Ministry of Environment (MOE) of Korea (NIER-2019-01-02-082). This work was also supported by the Soonchunhyang University Research Fund. This study was supported by a grant from the National Institute of Environmental Research funded by the Ministry of Environment (MOE) of Korea ( NIER - 2019-01-02-082 ). This work was also supported by the Soonchunhyang University Research Fund.

FundersFunder number
Ministry of Environment, Turkey
Soonchunhyang University
Ministry of Environment, TurkeyNIER - 2019-01-02-082
National Environmental Research Institute

    Keywords

    • Bisphenol A
    • Endocrine Disruptors
    • Parabens
    • Phthalates
    • Thyroid hormones

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