@article{d52263db8304458aa2895e1bec2e8273,
title = "Time Domains of Hypoxia Responses and -Omics Insights",
abstract = "The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.",
keywords = "adaptation, high altitude, hypoxia, integrative physiology, oxygen",
author = "Yu, {James J.} and Non, {Amy L.} and Heinrich, {Erica C.} and Wanjun Gu and Joe Alcock and Moya, {Esteban A.} and Lawrence, {Elijah S.} and Tift, {Michael S.} and O'Brien, {Katie A.} and Storz, {Jay F.} and Signore, {Anthony V.} and Khudyakov, {Jane I.} and Milsom, {William K.} and Wilson, {Sean M.} and Beall, {Cynthia M.} and Villafuerte, {Francisco C.} and Tsering Stobdan and Julian, {Colleen G.} and Moore, {Lorna G.} and Fuster, {Mark M.} and Stokes, {Jennifer A.} and Richard Milner and West, {John B.} and Jiao Zhang and Shyy, {John Y.} and Ainash Childebayeva and V{\'a}zquez-Medina, {Jos{\'e} Pablo} and Pham, {Luu V.} and Mesarwi, {Omar A.} and Hall, {James E.} and Cheviron, {Zachary A.} and Jeremy Sieker and Blood, {Arlin B.} and Yuan, {Jason X.} and Scott, {Graham R.} and Rana, {Brinda K.} and Ponganis, {Paul J.} and Atul Malhotra and Powell, {Frank L.} and Simonson, {Tatum S.}",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 Yu, Non, Heinrich, Gu, Alcock, Moya, Lawrence, Tift, O'Brien, Storz, Signore, Khudyakov, Milsom, Wilson, Beall, Villafuerte, Stobdan, Julian, Moore, Fuster, Stokes, Milner, West, Zhang, Shyy, Childebayeva, V{\'a}zquez-Medina, Pham, Mesarwi, Hall, Cheviron, Sieker, Blood, Yuan, Scott, Rana, Ponganis, Malhotra, Powell and Simonson.",
year = "2022",
month = aug,
day = "8",
doi = "10.3389/fphys.2022.885295",
language = "English",
volume = "13",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media SA",
}