Transmitter regulation of voltage-dependant K+ channels expressed in Xenopus oocytes

M. P. Kavanaugh, M. J. Christie, P. B. Osborne, A. E. Busch, K. Z. Shen, Y. N.P.H. Wu Seeburg, J. P. Adelman, R. A. North

Research output: Contribution to journalArticlepeer-review

Abstract

Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 μM, 20-30 s application) by up to 90 %. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.

Original languageEnglish
Pages (from-to)899-902
Number of pages4
JournalBiochemical Journal
Volume277
Issue number3
DOIs
StatePublished - 1991

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