Transmitter regulation of voltage-dependant K+ channels expressed in Xenopus oocytes

  • M. P. Kavanaugh
  • , M. J. Christie
  • , P. B. Osborne
  • , A. E. Busch
  • , K. Z. Shen
  • , Y. N.P.H. Wu Seeburg
  • , J. P. Adelman
  • , R. A. North

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 μM, 20-30 s application) by up to 90 %. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.

Original languageEnglish
Pages (from-to)899-902
Number of pages4
JournalBiochemical Journal
Volume277
Issue number3
DOIs
StatePublished - 1991

Funding

Funder number
R01HD024562

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