Turning a corner on HIV neutralization?

Jack H. Nunberg, Kathryn E. Follis, Meg Trahey, Rachel A. Lacasse

Research output: Contribution to journalReview articlepeer-review

Abstract

HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using 'fusion-competent' immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this goal may now be achievable. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalMicrobes and Infection
Volume2
Issue number2
DOIs
StatePublished - Feb 2000

Keywords

  • Antibodies
  • Envelope protein
  • Fusion
  • Human immunodeficiency virus
  • Vaccines
  • Virus neutralization

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