Turning a corner on HIV neutralization?

Jack H. Nunberg; Kathryn E. Follis; Meg Trahey; Rachel A. Lacasse

doi:10.1016/S1286-4579(00)00267-7

Turning a corner on HIV neutralization?

Jack H. Nunberg, Kathryn E. Follis, Meg Trahey, Rachel A. Lacasse

Montana Biotechnology Center

University of Montana

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using 'fusion-competent' immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this goal may now be achievable. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original language	English
Pages (from-to)	213-221
Number of pages	9
Journal	Microbes and Infection
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S1286-4579(00)00267-7
State	Published - Feb 2000

Keywords

Antibodies
Envelope protein
Fusion
Human immunodeficiency virus
Vaccines
Virus neutralization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S1286-4579(00)00267-7

Cite this

@article{f080439c987f42b6ae315316510ea60e,

title = "Turning a corner on HIV neutralization?",

abstract = "HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using 'fusion-competent' immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this goal may now be achievable. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",

keywords = "Antibodies, Envelope protein, Fusion, Human immunodeficiency virus, Vaccines, Virus neutralization",

author = "Nunberg, {Jack H.} and Follis, {Kathryn E.} and Meg Trahey and Lacasse, {Rachel A.}",

note = "Funding Information: The authors acknowledge the American Foundation for AIDS Research (amFAR) for their vision and support of our initial discovery of `fusion competent' immunogens. These studies were performed in collaboration with John Scarborough and Dr Dan Littman (NYU Medical Center, NY). We thank Dr Melinda Fagan for editorial review of the manuscript.",

year = "2000",

month = feb,

doi = "10.1016/S1286-4579(00)00267-7",

language = "English",

volume = "2",

pages = "213--221",

journal = "Microbes and Infection",

issn = "1286-4579",