Abstract
HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using 'fusion-competent' immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this goal may now be achievable. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
| Original language | English |
|---|---|
| Pages (from-to) | 213-221 |
| Number of pages | 9 |
| Journal | Microbes and Infection |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2000 |
Funding
The authors acknowledge the American Foundation for AIDS Research (amFAR) for their vision and support of our initial discovery of `fusion competent' immunogens. These studies were performed in collaboration with John Scarborough and Dr Dan Littman (NYU Medical Center, NY). We thank Dr Melinda Fagan for editorial review of the manuscript.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antibodies
- Envelope protein
- Fusion
- Human immunodeficiency virus
- Vaccines
- Virus neutralization
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