TY - JOUR
T1 - Understanding stoichiometric constraints on growth using resource use efficiency imbalances
AU - Prater, Clay
AU - Phan, Tin
AU - Elser, James J.
AU - Jeyasingh, Punidan D.
N1 - Publisher Copyright:
Copyright © 2024 the Author(s).
PY - 2024/5/7
Y1 - 2024/5/7
N2 - Growth is a function of the net accrual of resources by an organism. Energy and elemental contents of organisms are dynamically linked through their uptake and allocation to biomass production, yet we lack a full understanding of how these dynamics regulate growth rate. Here, we develop a multivariate imbalance framework, the growth efficiency hypothesis, linking organismal resource contents to growth and metabolic use efficiencies, and demonstrate its effectiveness in predicting consumer growth rates under elemental and food quantity limitation. The relative proportions of carbon (%C), nitrogen (%N), phosphorus (%P), and adenosine triphosphate (%ATP) in consumers differed markedly across resource limitation treatments. Differences in their resource composition were linked to systematic changes in stoichiometric use efficiencies, which served to maintain relatively consistent relationships between elemental and ATP content in consumer tissues and optimize biomass production. Overall, these adjustments were quantitatively linked to growth, enabling highly accurate predictions of consumer growth rates.
AB - Growth is a function of the net accrual of resources by an organism. Energy and elemental contents of organisms are dynamically linked through their uptake and allocation to biomass production, yet we lack a full understanding of how these dynamics regulate growth rate. Here, we develop a multivariate imbalance framework, the growth efficiency hypothesis, linking organismal resource contents to growth and metabolic use efficiencies, and demonstrate its effectiveness in predicting consumer growth rates under elemental and food quantity limitation. The relative proportions of carbon (%C), nitrogen (%N), phosphorus (%P), and adenosine triphosphate (%ATP) in consumers differed markedly across resource limitation treatments. Differences in their resource composition were linked to systematic changes in stoichiometric use efficiencies, which served to maintain relatively consistent relationships between elemental and ATP content in consumer tissues and optimize biomass production. Overall, these adjustments were quantitatively linked to growth, enabling highly accurate predictions of consumer growth rates.
KW - carbon
KW - ecological stoichiometry
KW - nitrogen
KW - nutritional physiology
KW - phosphorus
KW - Carbon/metabolism
KW - Animals
KW - Models, Biological
KW - Adenosine Triphosphate/metabolism
KW - Biomass
KW - Phosphorus/metabolism
KW - Nitrogen/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85191916244&partnerID=8YFLogxK
U2 - 10.1073/pnas.2319022121
DO - 10.1073/pnas.2319022121
M3 - Article
C2 - 38683986
AN - SCOPUS:85191916244
SN - 0027-8424
VL - 121
SP - e2319022121
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 19
M1 - e2319022121
ER -